There are
1,850 mi
from Simi Valley, CA to St Charles, MO
That's the driving distance. It would take 1 day 8 hours to go from Simi Valley, California to St Charles, Missouri.
The flight distance (direct flight from Simi Valley, CA to St Charles, MO) is 1,593.60 mi.
1,850 mi = 1.61 kms