There are
2,550 mi
from Simi Valley, CA to Sanford, FL
That's the driving distance. It would take 1 day 21 hours to go from Simi Valley, California to Sanford, Florida.
The flight distance (direct flight from Simi Valley, CA to Sanford, FL) is 2,227.93 mi.
2,550 mi = 3.22 kms