There are
2,010 mi
from Simi Valley, CA to Lisle, IL
That's the driving distance. It would take 1 day 11 hours to go from Simi Valley, California to Lisle, Illinois.
The flight distance (direct flight from Simi Valley, CA to Lisle, IL) is 1,739.54 mi.
2,010 mi = 3.22 kms