There are
2,397 mi
from Simi Valley, CA to Lexington, SC
That's the driving distance. It would take 1 day 18 hours to go from Simi Valley, California to Lexington, South Carolina.
The flight distance (direct flight from Simi Valley, CA to Lexington, SC) is 2,135.07 mi.
2,397 mi = 3.22 kms