There are
2,110 mi
from Simi Valley, CA to Jeffersonville, IN
That's the driving distance. It would take 1 day 13 hours to go from Simi Valley, California to Jeffersonville, Indiana.
The flight distance (direct flight from Simi Valley, CA to Jeffersonville, IN) is 1,851.37 mi.
2,110 mi = 3.22 kms