There are
2,655 mi
from Simi Valley, CA to Greenville, NC
That's the driving distance. It would take 1 day 23 hours to go from Simi Valley, California to Greenville, North Carolina.
The flight distance (direct flight from Simi Valley, CA to Greenville, NC) is 2,330.07 mi.
2,655 mi = 3.22 kms