There are
1,787 mi
from Simi Valley, CA to Greenville, MS
That's the driving distance. It would take 1 day 8 hours to go from Simi Valley, California to Greenville, Mississippi.
The flight distance (direct flight from Simi Valley, CA to Greenville, MS) is 1,586.96 mi.
1,787 mi = 1.61 kms