There are
2,406 mi
from Simi Valley, CA to Cayce, SC
That's the driving distance. It would take 1 day 18 hours to go from Simi Valley, California to Cayce, South Carolina.
The flight distance (direct flight from Simi Valley, CA to Cayce, SC) is 2,144.40 mi.
2,406 mi = 3.22 kms