There are
1,902 mi
from Simi Valley, CA to Cape Girardeau, MO
That's the driving distance. It would take 1 day 9 hours to go from Simi Valley, California to Cape Girardeau, Missouri.
The flight distance (direct flight from Simi Valley, CA to Cape Girardeau, MO) is 1,646.85 mi.
1,902 mi = 1.61 kms