There are
389 mi
from Shawnee, KS to Sikeston, MO
That's the driving distance. It would take 7 hours 22 mins to go from Shawnee, Kansas to Sikeston, Missouri.
The flight distance (direct flight from Shawnee, KS to Sikeston, MO) is 316.20 mi.
389 mi = 625.47 kms