There are
271 mi
from Shawnee, KS to Edwardsville, IL
That's the driving distance. It would take 5 hours 17 mins to go from Shawnee, Kansas to Edwardsville, Illinois.
The flight distance (direct flight from Shawnee, KS to Edwardsville, IL) is 256.38 mi.
271 mi = 435.46 kms