There are
262 mi
from Shawnee, KS to Cahokia, IL
That's the driving distance. It would take 5 hours 6 mins to go from Shawnee, Kansas to Cahokia, Illinois.
The flight distance (direct flight from Shawnee, KS to Cahokia, IL) is 245.64 mi.
262 mi = 422.44 kms