There are
390 mi
from Schaumburg, IL to Cape Girardeau, MO
That's the driving distance. It would take 7 hours 25 mins to go from Schaumburg, Illinois to Cape Girardeau, Missouri.
The flight distance (direct flight from Schaumburg, IL to Cape Girardeau, MO) is 335.42 mi.
390 mi = 628.04 kms