There are
956 mi
from Sarasota, FL to Sikeston, MO
That's the driving distance. It would take 17 hours 39 mins to go from Sarasota, Florida to Sikeston, Missouri.
The flight distance (direct flight from Sarasota, FL to Sikeston, MO) is 777.29 mi.
956 mi = 1,538.30 kms