There are
1,620 mi
from Santee, CA to Yankton, SD
That's the driving distance. It would take 1 day 4 hours to go from Santee, California to Yankton, South Dakota.
The flight distance (direct flight from Santee, CA to Yankton, SD) is 1,268.34 mi.
1,620 mi = 2,606.70 kms