There are
2,679 mi
from Santee, CA to Takoma Park, MD
That's the driving distance. It would take 1 day 23 hours to go from Santee, California to Takoma Park, Maryland.
The flight distance (direct flight from Santee, CA to Takoma Park, MD) is 2,257.98 mi.
2,679 mi = 4,312.02 kms