There are
1,730 mi
from Santee, CA to Sioux Falls, SD
That's the driving distance. It would take 1 day 6 hours to go from Santee, California to Sioux Falls, South Dakota.
The flight distance (direct flight from Santee, CA to Sioux Falls, SD) is 1,320.89 mi.
1,730 mi = 2,783.37 kms