There are
1,852 mi
from Santee, CA to Sikeston, MO
That's the driving distance. It would take 1 day 8 hours to go from Santee, California to Sikeston, Missouri.
The flight distance (direct flight from Santee, CA to Sikeston, MO) is 1,571.96 mi.
1,852 mi = 2,980.34 kms