There are
2,425 mi
from Santee, CA to Seminole, FL
That's the driving distance. It would take 1 day 18 hours to go from Santee, California to Seminole, Florida.
The flight distance (direct flight from Santee, CA to Seminole, FL) is 2,058.30 mi.
2,425 mi = 3,902.13 kms