There are
1,293 mi
from Santee, CA to Seguin, TX
That's the driving distance. It would take 21 hours 54 mins to go from Santee, California to Seguin, Texas.
The flight distance (direct flight from Santee, CA to Seguin, TX) is 1,144.21 mi.
1,293 mi = 2,081.39 kms