There are
2,095 mi
from Santee, CA to Panama City Beach, FL
That's the driving distance. It would take 1 day 12 hours to go from Santee, California to Panama City Beach, Florida.
The flight distance (direct flight from Santee, CA to Panama City Beach, FL) is 1,838.60 mi.
2,095 mi = 3,372.03 kms