There are
2,340 mi
from Santee, CA to Palatka, FL
That's the driving distance. It would take 1 day 17 hours to go from Santee, California to Palatka, Florida.
The flight distance (direct flight from Santee, CA to Palatka, FL) is 2,089.36 mi.
2,340 mi = 3,766.34 kms