There are
1,551 mi
from Santee, CA to Neosho, MO
That's the driving distance. It would take 1 day 3 hours to go from Santee, California to Neosho, Missouri.
The flight distance (direct flight from Santee, CA to Neosho, MO) is 1,308.33 mi.
1,551 mi = 2,495.46 kms