There are
1,362 mi
from Santee, CA to Mesquite, TX
That's the driving distance. It would take 23 hours 16 mins to go from Santee, California to Mesquite, Texas.
The flight distance (direct flight from Santee, CA to Mesquite, TX) is 1,181.45 mi.
1,362 mi = 2,192.02 kms