There are
2,424 mi
from Santee, CA to Lexington, NC
That's the driving distance. It would take 1 day 18 hours to go from Santee, California to Lexington, North Carolina.
The flight distance (direct flight from Santee, CA to Lexington, NC) is 2,093.06 mi.
2,424 mi = 3,901.12 kms