There are
2,679 mi
from Santee, CA to Hyattsville, MD
That's the driving distance. It would take 1 day 23 hours to go from Santee, California to Hyattsville, Maryland.
The flight distance (direct flight from Santee, CA to Hyattsville, MD) is 2,261.35 mi.
2,679 mi = 4,311.66 kms