There are
1,819 mi
from Santee, CA to Farmington, MO
That's the driving distance. It would take 1 day 8 hours to go from Santee, California to Farmington, Missouri.
The flight distance (direct flight from Santee, CA to Farmington, MO) is 1,529.98 mi.
1,819 mi = 2,927.73 kms