There are
2,656 mi
from Santee, CA to Ephrata, PA
That's the driving distance. It would take 1 day 23 hours to go from Santee, California to Ephrata, Pennsylvania.
The flight distance (direct flight from Santee, CA to Ephrata, PA) is 2,300.54 mi.
2,656 mi = 4,275.18 kms