There are
1,838 mi
from Santee, CA to Cahokia, IL
That's the driving distance. It would take 1 day 8 hours to go from Santee, California to Cahokia, Illinois.
The flight distance (direct flight from Santee, CA to Cahokia, IL) is 1,547.94 mi.
1,838 mi = 2,957.24 kms