There are
1,537 mi
from Santee, CA to Brownsville, TX
That's the driving distance. It would take 1 day 2 hours to go from Santee, California to Brownsville, Texas.
The flight distance (direct flight from Santee, CA to Brownsville, TX) is 1,264.33 mi.
1,537 mi = 2,474.26 kms