There are
1,373 mi
from Santee, CA to Brenham, TX
That's the driving distance. It would take 23 hours 41 mins to go from Santee, California to Brenham, Texas.
The flight distance (direct flight from Santee, CA to Brenham, TX) is 1,224.12 mi.
1,373 mi = 2,208.96 kms