There are
2,007 mi
from Santa Maria, CA to Cape Girardeau, MO
That's the driving distance. It would take 1 day 11 hours to go from Santa Maria, California to Cape Girardeau, Missouri.
The flight distance (direct flight from Santa Maria, CA to Cape Girardeau, MO) is 1,725.34 mi.
2,007 mi = 3,229.38 kms