There are
1,485 mi
from Santa Fe, NM to Waynesville, NC
That's the driving distance. It would take 1 day 2 hours to go from Santa Fe, New Mexico to Waynesville, North Carolina.
The flight distance (direct flight from Santa Fe, NM to Waynesville, NC) is 1,286.61 mi.
1,485 mi = 1.61 kms