There are
1,648 mi
from Santa Fe, NM to Roanoke, VA
That's the driving distance. It would take 1 day 5 hours to go from Santa Fe, New Mexico to Roanoke, Virginia.
The flight distance (direct flight from Santa Fe, NM to Roanoke, VA) is 1,443.87 mi.
1,648 mi = 1.61 kms