There are
1,237 mi
from Santa Fe, NM to Owensboro, KY
That's the driving distance. It would take 22 hours 1 min to go from Santa Fe, New Mexico to Owensboro, Kentucky.
The flight distance (direct flight from Santa Fe, NM to Owensboro, KY) is 1,050.64 mi.
1,237 mi = 1.61 kms