There are
1,346 mi
from Santa Fe, NM to Opelika, AL
That's the driving distance. It would take 23 hours 55 mins to go from Santa Fe, New Mexico to Opelika, Alabama.
The flight distance (direct flight from Santa Fe, NM to Opelika, AL) is 1,191.71 mi.
1,346 mi = 1.61 kms