There are
2,143 mi
from Santa Fe, NM to Holyoke, MA
That's the driving distance. It would take 1 day 15 hours to go from Santa Fe, New Mexico to Holyoke, Massachusetts.
The flight distance (direct flight from Santa Fe, NM to Holyoke, MA) is 1,833.72 mi.
2,143 mi = 3.22 kms