There are
1,036 mi
from Santa Fe, NM to Cahokia, IL
That's the driving distance. It would take 18 hours 14 mins to go from Santa Fe, New Mexico to Cahokia, Illinois.
The flight distance (direct flight from Santa Fe, NM to Cahokia, IL) is 888.87 mi.
1,036 mi = 1.61 kms