There are
2,132 mi
from Santa Cruz, CA to Edwardsville, IL
That's the driving distance. It would take 1 day 13 hours to go from Santa Cruz, California to Edwardsville, Illinois.
The flight distance (direct flight from Santa Cruz, CA to Edwardsville, IL) is 1,744.71 mi.
2,132 mi = 3,431.60 kms