There are
2,090 mi
from Santa Cruz, CA to Cahokia, IL
That's the driving distance. It would take 1 day 12 hours to go from Santa Cruz, California to Cahokia, Illinois.
The flight distance (direct flight from Santa Cruz, CA to Cahokia, IL) is 1,733.79 mi.
2,090 mi = 3,363.38 kms