There are
2,255 mi
from Santa Clarita, CA to Greeneville, TN
That's the driving distance. It would take 1 day 15 hours to go from Santa Clarita, California to Greeneville, Tennessee.
The flight distance (direct flight from Santa Clarita, CA to Greeneville, TN) is 2,006.74 mi.
2,255 mi = 3.22 kms