There are
1,881 mi
from Santa Clarita, CA to Cape Girardeau, MO
That's the driving distance. It would take 1 day 9 hours to go from Santa Clarita, California to Cape Girardeau, Missouri.
The flight distance (direct flight from Santa Clarita, CA to Cape Girardeau, MO) is 1,631.49 mi.
1,881 mi = 1.61 kms