There are
2,444 mi
from Santa Clara, CA to Knoxville, TN
That's the driving distance. It would take 1 day 18 hours to go from Santa Clara, California to Knoxville, Tennessee.
The flight distance (direct flight from Santa Clara, CA to Knoxville, TN) is 2,096.07 mi.
2,444 mi = 3,934.00 kms