There are
2,250 mi
from Santa Ana, CA to Greeneville, TN
That's the driving distance. It would take 1 day 15 hours to go from Santa Ana, California to Greeneville, Tennessee.
The flight distance (direct flight from Santa Ana, CA to Greeneville, TN) is 1,980.43 mi.
2,250 mi = 3,621.56 kms