There are
1,318 mi
from Sanford, FL to Appleton, WI
That's the driving distance. It would take 1 day 1 hour to go from Sanford, Florida to Appleton, Wisconsin.
The flight distance (direct flight from Sanford, FL to Appleton, WI) is 1,140.69 mi.
1,318 mi = 2,121.01 kms