There are
2,261 mi
from San Mateo, CA to Zionsville, IN
That's the driving distance. It would take 1 day 15 hours to go from San Mateo, California to Zionsville, Indiana.
The flight distance (direct flight from San Mateo, CA to Zionsville, IN) is 1,936.89 mi.
2,261 mi = 3.22 kms