There are
2,497 mi
from San Mateo, CA to Willoughby, OH
That's the driving distance. It would take 1 day 19 hours to go from San Mateo, California to Willoughby, Ohio.
The flight distance (direct flight from San Mateo, CA to Willoughby, OH) is 2,175.95 mi.
2,497 mi = 3.22 kms