There are
3,227 mi
from San Mateo, CA to Waterville, ME
That's the driving distance. It would take 2 days 10 hours to go from San Mateo, California to Waterville, Maine.
The flight distance (direct flight from San Mateo, CA to Waterville, ME) is 2,739 mi.
3,227 mi = 4.83 kms