There are
2,494 mi
from San Mateo, CA to Twinsburg, OH
That's the driving distance. It would take 1 day 19 hours to go from San Mateo, California to Twinsburg, Ohio.
The flight distance (direct flight from San Mateo, CA to Twinsburg, OH) is 2,176.82 mi.
2,494 mi = 3.22 kms