There are
2,328 mi
from San Mateo, CA to Trussville, AL
That's the driving distance. It would take 1 day 16 hours to go from San Mateo, California to Trussville, Alabama.
The flight distance (direct flight from San Mateo, CA to Trussville, AL) is 2,013.03 mi.
2,328 mi = 3,745.80 kms